Critically, these disabling symptoms often respond poorly to dopaminergic drugs, and advanced therapy, including subthalamic nucleus deep brain stimulation (DBS). However, there are PD-specific factors that contribute to the onset of these symptoms, including deficits of central sensory processing and motor deficits such as freezing of gait (FoG). ![]() Gait problems, postural instability, and falls in PD, like in the non-PD elderly population, are multi-factorial. The socioeconomic cost of falls in PD is also significant, with 80% of spending on PD care arising from acute admissions, primarily falls related. Average survival is reduced to 7 years once a PD patient starts having falls. Unfortunately, the occurrence of these symptoms represents a major milestone in PD progression, resulting in loss of independence, worsened quality of life, and markedly increased mortality (from the consequences of falls e.g. However, as the disease progresses, more debilitating symptoms occur, including gait problems, postural instability, and falls. These symptoms can be effectively treated with dopamine replacement therapy, at least in the initial stages of the disease. The pathological hallmark of PD is the loss of dopaminergic projection neurons in the substantia nigra, manifesting as the classic triad of bradykinesia, rigidity and tremor. Based on records from the nationwide Danish Hospital Register, 1,931 patients with a first-time diagnosis of PD were seen in Danish hospitals between 20, and according to the Danish Parkinson Association, more than 8,000 people live in Denmark with PD, but many more people, including relatives and caregivers, are affected by the burden of the disease. ![]() ![]() Parkinson's disease (PD) is a chronic neurodegenerative disorder affecting almost 2% of all people over the age of 65 worldwide.
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